Diagnostic and Interventional Radiology Research Group

Tropical Disease and Global Health Radiology Imaging Research Group

Advancing Radiology Imaging for Tropical Diseases, Travel-Related Diseases, and Emerging Infections

Brief Description

This research group, part of the Diagnostic and Interventional Radiology KBK at the Faculty of Medicine, Universitas Udayana, focuses on the development and utilization of radiology imaging for the diagnosis, evaluation, and monitoring of tropical diseases, travel-related infections, and emerging/re-emerging diseases. Research focuses include tuberculosis, parasitic infections, zoonotic diseases, emerging viral infections, and musculoskeletal or systemic manifestations of tropical diseases. The group integrates precision radiology, quantitative imaging, radiomics, and artificial intelligence to improve diagnostic accuracy and support healthcare systems in tropical and global settings. With Bali’s strategic position as an international destination, this group holds a key role in advancing tropical disease radiology research at national and international levels.

Background

Tropical diseases and travel-related infections remain global health challenges, particularly in Southeast Asia. High human mobility, climate change, urbanization, and human–animal interaction increase the risk of emerging and re-emerging diseases such as tuberculosis, dengue, chikungunya, leptospirosis, parasitosis, and novel viral infections. Radiology plays a crucial role in early detection, organ characterization, complication assessment, and therapy monitoring.

However, imaging interpretation of tropical diseases is often descriptive and not quantitatively standardized. The development of quantitative imaging biomarkers, radiomics, and AI offers opportunities to improve diagnostic accuracy, differentiate infectious etiologies, and predict clinical outcomes. This innovation aligns with global trends toward precision radiology and evidence-based clinical decision support.

As a tropical region with a high infectious disease burden and an international tourism hub, Indonesia—particularly Bali—faces unique challenges in diagnosing tropical and travel-related diseases. Comprehensive radiology imaging research is therefore highly relevant to support early detection, outbreak preparedness, and improved healthcare quality.

This research group aligns with the vision of the Faculty of Medicine, Universitas Udayana, in developing leading research based on regional health issues, strengthening health technology innovation, and integrating education, research, and clinical service.

Vision

To become a national center of excellence in the development of precision radiology imaging for the diagnosis and evaluation of tropical diseases, travel medicine, and emerging infections.

Mission

1.      Develop leading radiology research on tropical diseases and travel-related infections.

2.      Develop quantitative imaging biomarkers and radiomics for infection diagnosis.

3.      Integrate research results into Radiology residency education and clinical services.

4.      Produce internationally reputable scientific publications and imaging technology innovations.

5.      Strengthen national and international collaborations in tropical radiology.

Research Roadmap

Short-Term (1–2 Years)

Focus: Imaging pattern mapping and protocol standardization

• Identify and characterize imaging patterns of endemic tropical diseases (tuberculosis, dengue, leptospirosis, parasitic, and fungal infections).
• Document radiological manifestations of travel-related infections in international and domestic patients.
• Develop imaging databases for tropical and emerging infections in local populations.
• Standardize CT, MRI, and USG protocols for tropical infectious disease evaluation.
• Integrate case-based research into Radiology residency education.

Outcome: Regional imaging atlas & standard imaging protocols for tropical diseases.

Medium-Term (3–5 Years)

Focus: Diagnostic validation and infectious etiology differentiation

• Identify imaging parameters to differentiate bacterial, viral, parasitic, and fungal infections.
• Validate quantitative imaging biomarkers to assess disease activity and therapy response.
• Differentiate imaging features between tropical diseases and non-infectious conditions (neoplasms, autoimmune inflammation).
• Conduct national multicenter collaborations for tropical and emerging infections.
• Develop predictive models for complications and clinical outcomes based on imaging.

Outcome: Evidence-based radiology diagnostic algorithms for tropical infectious diseases.

Long-Term (5+ Years)

Focus: Precision radiology, AI, and outbreak preparedness

• Develop radiomics signatures for tropical and emerging infectious diseases.
• Develop AI tools for early detection and classification of emerging infections.
• Implement imaging-based decision-support systems to guide clinical decision-making.
• Integrate imaging surveillance into outbreak preparedness and public health systems.
• Contribute to national and regional guidelines on tropical disease imaging.

Outcome: Clinical implementation, AI-based decision support systems, and contributions to national guidelines.

Research Group Member

Reseach Group Leader

• Name                           : Dr. dr. Elysanti Dwi Martadiani, Sp.Rad (K) MSK
• NIDN/NIP                  : 0021037412 / 197403212005012002
• Academic position      : Associate Professor
• Speciality                    : Musculoskeletal Radiology
• Email                           : elysantidm@gmail.com

Member

Partner / Collaborators

Publication

Afandi, R., Astawa, P., Wiratnaya, I. G. E., Suyasa, I. K., Martadiani, E. D, Ayusta, I. M. D., & Maharjana, M. A. (2023). The Association between Achilles Tendon Elasticity and Pirani Score with The Need for Achilles Tendon Lengthening in Patients with Congenital Talipes Equinovarus Post Ponseti Serial Casting. European Journal of Medical and Health Sciences, 5(2), 54-57. DOI: 10.24018/ejmed.2023.5.2.1696

Anggreini, F. N., Dewi, P. U., Sitanggang, F. P., & Suadiatmika, D. G. M. (2025). A Case Report: Serial Case of Spontaneous Pneumomediastinum and Subcutaneous Emphysema in COVID-19 Patients. Indonesian Journal of Global Health Research, 7(2), 793-804. https://doi.org/10.37287/ijghr.v7i2.5924

Anggreini, F. N., Martadiani, E. D., & Suadiatmika, D. G. M. (2025). From Dual Energy X-Ray Absorptiometry to Positron Emission Tomography: Diverse Imaging Approaches to Body Composition. Indonesian Journal of Global Health Research, 7(6), 1103–1110. https://doi.org/10.37287/ijghr.v7i6.1172

Asih K. P., Asih, M. W, Martadiani, E. D. (2023). MRI imaging pattern of metastasis and tuberculous spondylitis in the spine: serial case report. Intisari Sains Medis, 14(3), 1393-1396.

Asih, M. W., Martadiani, E. D., Laksminingsih, N. S., Sulaiman, Y. W., & Trisnawati, I. G. A. (2021). Reliability of cerebral edema interpretation on head computed tomography scan in mild and moderate traumatic brain injury. Bali Medical Journal, 10(3), 1067-1069. DOI: 10.15562/bmj.v10i3.2685

Asih, M. W., Martadiani, E. D., Putra, I. W. G. A. E., Nike, F., Ratnasari, P. A., Raturandang, N. A., Liusen, J., Khrisna, A. A. G. P. S., Kanti, L. D. A. S., & Kartadinata, A. (2025). Correlation of magnetic resonance imaging parameters with Montreal Cognitive Assessment–Indonesian (MoCA-INA) score in dementia patients at Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali, Indonesia. Egyptian Journal of Radiology and Nuclear Medicine. DOI: 10.1186/s43055-025-01433-0

Darmawan, M. R., Martadiani, E. D., Ayusta, M. D. P., Widiana, G. R., Setiawan, C. R., & Aryana, G. N. W. (2022). Diagnostic Value of Lachmeter in Measuring Anterior Tibia Translation on Post-Anterior Cruciate Ligament Tear Reconstruction Compared to CT Scan. Open Access Macedonian Journal of Medical Sciences, 10(B), 1813-1817. https://doi.org/10.3889/oamjms.2022.9758

Delia N. L. P., Martadiani, E. D., Asih, M. W., Anggreini, F. N., (2024). Magnetic Resonance Imaging (MRI) Images in Tuberculosis Spondylitis Patients at the Central General Hospital Prof. Dr. I.G.N.G. Ngoerah Year 2021-2023. International Journal of Research and Review. DOI: https://doi.org/10.52403/ijrr.20240402

Harlan, J., Ayusta, I. M. D., Martadiani, E. D., Widiana, I. G. R., Asih, M. W., & Sitanggang, F. P. The Difference of Mean WSS Value on The Carotid Bifurcation and The Medial Segment of Common Carotid Artery Using Vector Flow Ultrasonography in Hypertensive Patients at Prof Dr. IGNG Ngoerah General Hospital February-April 2022. DOI: 10.51542/ijscia.v5i4.3

Indraswari, P. G., Krisdanti, I. D. P. A., & Anggreini, F. N. (2026). Diagnostic Role of Lung Ultrasound in Pneumonia . Indonesian Journal of Global Health Research, 8(1), 787–792. https://doi.org/10.37287/ijghr.v8i1.1453

Juniada, P. H., Asih, M. W., Margiani, N. N., Putra, I. W. G. A. E., Martadiani, E. D., & Wijaya, I. G. A. G. M. Korelasi aspect score dengan NIHSS, GCS, dan lama dirawat pada pasien stroke non hemoragik akut di RSUP Sanglah. Avaiable from: doi:10.24843.MU.2022.V11.i10.P02

Kartika, I., Asih, M. W., Martadiani, E. D., Anandasari, P. P. Y., Patriawan, P., & Widiana, I. G. R. Increase of Carotid Intima-Media Thickness and Reduction of Carotid Artery Lumen Diameter in Breast Cancer Patient Before and After Chemotherapy. Avaiable from: https:// doi.org/10.24843/JBN.2022.v06.i01.p02

Laela, T. R. N., Martadiani, E. D., Sudiatmika, D. G. M. (2025). Gambaran radiologi tulang belakang pada pasien skoliosis di RSUP Sanglah Bali. E-Jurnal Medika. DOI: 10.24843/MU.2025.V14.i4.P03

Mahardika, I. G., Suyasa, I. K., Wiratnaya, I. G. E, Martadiani, E. D. (2025). The risk factor of ligamentum flavum thickness, disc herniation degree, intervertebral disc space narrowing, and stenosis level. International Journal of Research. DOI: 10.52403/ijrr.20250421

Nike, F., Asih, M. W., Sitanggang, F. P., Eka Putra, I. W. G. A., Triningrat, A. A. M, Martadiani, E. D. (2025). Exploring the relationship between optic nerve geometry, proptosis, and intraocular pressure in optic neuropathy through MRI. Romanian Journal of Neurology. https://doi.org/10.37897/RJN.2025.2.13

Parami, P., Senapathi, T. G. A., Duarsa, G. W. K., Wande, I. N., Martadiani, E. D., Arif, S. K., Chandra, S. O., & Widjanarko, S. D. (2025). Urinary neutrophil gelatinase-associated lipocalin level is associated with the incidence of postoperative acute kidney injury: An observational study. Bali Journal of Anesthesiology. https://doi.org/10.4103/bjoa.bjoa_77_25

Parami, P., Senapathi, T. G. A., Duarsa, G. W. K., Wande, I. N., Martadiani, E. D., Arif, S. K., Bumi, D. M., & Jonathan, J.  (2025). Renal resistive index as a clinical biomarker in acute kidney injury. Neurologico Spinale Medico Chirurgico. DOI: https://doi.org/10.4103/nsmc.nsmc_1_25

Pemayun, C. K. D., Wiratnaya, I. G. E., Mulyadi, K. G., Ridia, Martadiani, E. D., & Kurniawan, K. I. S. Decreased Isokinetic Strength of 1st Ray Plantar Flexion and Decreased Eversion Are Predictors of Unregenerated Peroneus Longus Tendon After 1 Year of Anterior Cruciate Ligament Reconstruction.Avaiable from https://doi.org/10.52403/ijrr.20220753

Putu Ayu Winda Wirastuti Giri, Dwija Putra Ayusta. (2020). Evaluasi Radiologi pada Trauma Tembus Kompleks Nasoorbitoethmoid. Medicina Udayana. Vol 51(3), 601-604. https://doi.org/10.15562/medicina.v51i3.942

Samantha, V., Sitanggang, F. P., Martadiani, E. D., Asih, M. W. (2023). Pencitraan Computed Tomography Pada Pasien Trauma Thoracolumbar RSUP PROF. DR. IGNG Ngoerah Tahun 2022. Health Information: Jurnal Penelitian. https://myjurnal.poltekkes-kdi.ac.id/index.php/hijp

Saptono Putra, M. S., Martadiani, E. D., Ayusta, I. M. D., Eka Putra, I. W. G. A., & others. (2025). The relationship between subcutaneous and visceral fat thickness and osteoporosis incidence in women aged ?50 years at RSUP Prof. Dr. I.G.N.G. Ngoerah. Journal of Universal Studies. https://doi.org/10.59188/eduvest.v5i11.52208

Shesaria, P. S., Martadiani, E. D., & Patriawan, P. (2025). Pencitraan multimodalitas untuk evaluasi radiologi pasca rekonstruksi anterior cruciate ligament (ACL): Serial kasus. Intisari Sains Medis. DOI: 10.15562/ism.v16i1.2235

Sitanggang, F. P., Sudiatmika, D. G. M. ., Anggreini, F. N. ., & Tampubolon, D. J. . (2023). The finding of subcutaneous emphysema on chest X-rays of COVID-19 patients at Prof. Dr. I.G.N.G Ngoerah General Hospital. Indonesia Journal of Biomedical Science, 17(2), 248–252. https://doi.org/10.15562/ijbs.v17i2.490

Sitanggang, F. P., Utama, P. C. B, Anggreini, F. N., Icksan, A. G. (2022). PERANAN Pencitraan  Radiologi dalam COVID-19. Baswara Press, 978-623-88210-0-6, Hlm. 1-63, https://doi.org/10.53638/BWP.63

Tanamas, B., Suyasa, I. K., & Wiratnaya, I. G. E, Martadiani, E. D. (2025). Predictors of Japanese Orthopaedic Association score improvement in cervical spondylotic myelopathy patients after laminoplasty. International Journal of Research. DOI:  10.52403/ijrr.20250420

Terisno, E., Anandasari, P. P. Y., Margiani, N. N., Ayusta, I. M. D, Martadiani, E. D. (2025). Correlation between Reid–Eustachian tube angle, length, and diameter based on temporal bone CT scan with severity level in chronic suppurative otitis media. Asian Journal of Engineering, Social and Health. https://doi.org/10.46799/ajesh.v4i11.694

Tjan, A., Martadiani, E. D., & Asih, N. M. W. (2021). Imaging of multi-etiologies of pneumatosis intestinalis in children with AIDS: case report and review. Medicina, 52(2), 127-131. DOI: 10.15562/medicina.v52i2.671

Tjan, A., Widiana, I. G. R., Martadiani, E. D., Ayusta, I. M. D., Asih, M. W., & Sitanggang, F. P. (2021). Carotid artery stiffness measured by strain elastography ultrasound is a stroke risk factor. Clinical Epidemiology and Global Health, 12, 100850. https://doi.org/10.1016/j.cegh.2021.100850

Vania, R., Sanjaya, I. G., Hamid, A. R., Sudarsa, S. D., Dewi, I. G., Niryana, I. W., Martadiani, E. D. (2024). Early activation of macrophage-2 with IL-4 in stromal vascular fraction increases VEGF levels and adipocyte count and maintains volume of fat graft in Wistar rats (Rattus norvegicus). Narra J, 4(3), e1080. doi: 10.52225/narra.v4i3.1080

Widyasari, N. N., Martadiani, E. D., Asih, M. W., Widiana, I. G. R., Sitanggang, F. P., & Patriawan, P. (2021). Correlation between loss of cervical lordosis and the degree of cervical disc herniation. IJBS, 15(1), 43-47. DOI: 10.15562/ijbs.v15i1.288

Undergoing Research

1.    Research Title: A Randomized, Double-Blind, Multicenter, Phase II/III Clinical Study of UCMSC Derived Secretome versus Sodium Hyaluronate in Patients with Grade 2–3 Kellgren Lawrence Knee Osteoarthritis.

Funding Scheme: Grant

Year: 2025–2026

Role of the Research Group: Conduct standardization and evaluation of knee imaging, assess structural changes and therapy response based on imaging, and ensure the quality and analysis of radiological data in the multicenter study.

2     Research Title: Comprehensive Intervention Strategy to Improve Retention in the TB Infection Cascade of Care in High-Risk Groups through a Person-Centered Approach in SEAR Countries (CRITIC Study).

Funding Scheme: Grant

Year: 2025–2026

Role of the Research Group: Provide radiological diagnostic support for early TB detection, standardize imaging protocols, and ensure quality of imaging interpretation within a patient-centered TB care approach.

Intellectual Property (IP) / Innovation

Community Health Programme

Collaboration

Domestic Partners

·         RSUP Prof. Dr. I.G.N.G. Ngoerah

·         Perhimpunan Dokter Spesialis Radiologi Indonesia

International Partners (Potential)

·         Asian Musculoskeletal Society

·         European Society of Musculoskeletal Radiology

Forms of Collaboration

·         Multicenter research

·         Scientific publications

·         Training & workshops

·         Data & technology exchange

Contact

·       Address: Secretariat of the Department/KSM of Radiology, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Jalan Diponegoro, Denpasar, Bali 80114, Tel. +62 361 229711 ext. 384

·      Research Group Email: smfradiologi@gmail.com

·      Website: radiologi.unud.ac.id

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